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Congratulations to Kate on her recent publication in JCI! An inconsistency in staining led to the identification of unusual, shortened (s) TDP43 splice isoforms that may play a central role in ALS pathogenesis. Way to go, Kate!    Congratulations, Kate! Kate Weskamp successfully defended her thesis today. The first question was asked by none other than Ripley Barmada. Despite the fact that this question had something to do with reindeer, and wasn't even directed at Kate, this kicked off a lively round of questions by audience members and (after a short delay) thesis committee members. Not surprisingly, Kate came out of it with a PhD.
According to Hitachi, an F31 is "A compact system with outstanding performance, for a wide range of applications."  In this case, however, the F31 is no diagnostic ultrasound system, but a competitive grant from the NIH. Congratulations, Nico!  The best happy hour conversations start and end with UPF1.
Hosted at Mt. Snow, Vermont, the 2nd Gordon Research Conference on ALS and related motor neuron diseases (July 21-26, 2019) attracted investigators from around the world. Kate gave an invited talk at the Gordon Research Seminar that preceded the conference, Nico gave a short talk based on his poster, Mike and Ahmed both presented posters, and Sami led the session on RNA metabolism. Not a bad showing!  LATE (limbic predominant age-associated TDP43 encephalopathy) is a recently described condition that may be responsible for memory decline in the oldest old (>85 years). While the prevalence of Alzheimer's decreases in this demographic, LATE continues to rise. But because LATE looks clinically indistinguishable from Alzheimer's, many people are inadvertently diagnosed with Alzheimer's, treated as if they have Alzheimer's, and are enrolled in studies for new treatments in Alzheimer's. While we have known that TDP43 is involved in ALS, frontotemporal dementia and perhaps Alzheimer's, this is one of the first indications that TDP43 may be primarily responsible for a disorder of memory in a growing fraction of the population. You can read about LATE and its implications below.
   All dressed up... and places to go! Congrats Brittany!
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AuthorThe Barmada Lab Archives
November 2019
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